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However, changes in nail structure, a sign of toxicity, were reported with a selenium intake of 900 mcg per day in China

Brendler, T., & Williamson, E

For example, in cultured endothelial cells, lipoic acid was found to inhibit IKK-, an enzyme that promotes the translocation of redox-sensitive and pro-inflammatory transcription factor, nuclear factor-kappa B (NFB) from the cytosol to the nucleus (46)